Investor FAQs

Hereditary Angioedema (HAE) is a rare genetic condition which occurs in approximately 1 in 30,000 people worldwide. Symptoms include episodes of swelling in the hands, feet, abdomen, face and airway. Patients may suffer bouts of excruciating abdominal pain, nausea and vomiting that is exacerbated by swelling in the intestinal wall. Airway (laryngeal) swelling is particularly dangerous and can lead to death by asphyxiation.

C1 inhibitor is normally found in our blood.  Patients with HAE, however, have low levels of functioning C1 inhibitor.  There are many triggers for an attack including stress, medications, trauma, hormone changes etc.  An attack begins with the activation of (FXII and Kallikrein) that are normally kept in check by C1 inhibitor (C1-INH).  Eventually, because there is not enough C1-INH available, this activation leads to the production of bradykinin, which leads to fluid leaking out of the blood vessels and into the tissues (angioedema).

Recombinant technology is a state of the art, efficient way to produce complex human proteins such as C1-INH without the need for human plasma donations. This technology has been used for more than 30 years to make medicines that treat a wide variety of conditions such as asthma, diabetes, hemophilia, and cancer.  

Ruconest (conestat alfa) is a recombinant human C1 esterase inhibitor approved for the treatment of angioedema attacks in patients with HAE in the US, Israel, all 28 EU countries plus Norway, Iceland and Liechtenstein.

RUCONEST® (conestat alfa) is a recombinant human C1 esterase inhibitor (rhC1INH). C1 esterase inhibitor (C1INH) is a protein that naturally occurs in the human body. It belongs to the class of serine-protease inhibitors or serpins. It regulates several inflammatory pathways in the body by inhibiting certain proteins (proteases) that are part of the human immune system. Deficiency of functional C1 inhibitor leads to excessive activation of the complement system and other immunological and haemostatic pathways, giving cause to angioedema attacks.

In the Netherlands

Pharming’s shares are listed on Euronext Amsterdam since 1999. The opening share price was 0,883366

Pharming’s shares are listed on Euronext Amsterdam Under the symbol PHARM, since 1999. The shares (ISIN Code: NL0010391025) are only traded through the book-entry facilities of Euroclear Nederland.

You can find the latest press releases here; https://www.pharming.com/news

You can find all financial reports here; https://www.pharming.com/investors/financial-documents

You can find the SEC filings here

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Should you have any further questions please don’t hesitate to contact us at investor@pharming.com 

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The next shareholder meeting, the AGM, will take place on the 19th of May 2021. You can find all our events on the Pharming website.